The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 1998
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Darren Magda, Cupertino, CA (US);
Jonathan L Sessler, Austin, TX (US);
Meredith Wright, San Jose, CA (US);
Richard A Miller, Portola Valley, CA (US);
William C Dow, Fremont, CA (US);
Assignees:
Board of Regents, The University of Texas System, Austin, TX (US);
Pharmacyclics, Inc., Sunnyvale, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; C07H / ; A01N / ;
U.S. Cl.
CPC ...
435-6 ; 536 221 ; 536 231 ; 536 243 ; 536 2532 ; 514-1 ; 514 44 ;
Abstract
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a metallotexaphyrin complex under conditions and for a time sufficient to hydrolyze the phosphate ester. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution. Phosphate ester substrates include nucleic acid such as RNA, phosphoric anhydrides, phospholipids, and alkyl phosphate esters.