The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 1998
Filed:
Jan. 30, 1996
Applicant:
Inventor:
Gordon A Vehar, San Carlos, CA (US);
Assignee:
Genentech, Inc., South San Franciso, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; C07K / ;
U.S. Cl.
CPC ...
424 851 ; 4241981 ; 424 852 ; 424 855 ; 4241581 ; 514 12 ; 530350 ; 530351 ; 530381 ;
Abstract
The invention concerns a method for inducing a selective collapse of the vasculature of a solid tumor by administering to a patient a therapeutically effective dose of a combination of a compound preventing the formation of a functional thrombin-thrombomodulin complex and a cytokine selected from the group of TNF-.beta. (LT), TNF-.alpha., IL-1, and IFN-.gamma.. The invention further concerns the composition used in this method.