The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 1998
Filed:
Aug. 09, 1993
Michael D Pierschbacher, San Diego, CA (US);
John J Grzesiak, Cardiff, CA (US);
Daniel Kirchhofer, Obervil, CH;
La Jolla Cancer Research Foundation, La Jolla, CA (US);
Abstract
The invention relates to the regultory role of cations on the dynamics of integrin-mediated cell adhesion and migration. In one aspect, methods of promoting or inhibiting the migration of integrin-expressing cells are provided by controlling the amount of cations, such as Mg.sup.2+ or Ca.sup.2+, in contact with the integrins of the cells. Methods of modifying the binding avidity of an integrin for its ligand are also provided by regulating the concentration of cations in contact with the integrin. The invention further relates to methods of using cations for a variety of applications and in particular for promoting wound healing.