The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 1998
Filed:
Apr. 20, 1995
Applicant:
Inventors:
William A Haseltine, Cambridge, MA (US);
Christopher M Farnet, Cambridge, MA (US);
Assignee:
Dana Farber Cancer Institute, Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q / ; C12Q / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435-5 ; 435-6 ; 4352351 ; 435325 ;
Abstract
An assay for factors that affect integration of DNA into target DNA is disclosed. Assays for methods of screening for factors which effect viral DNA circularization either by homologous recombination, end-to-end ligation, or autointegration, are also disclosed. A method for screening for factors which will enhance circularization rather than integration by testing cellular cytoplasmic fluid under conditions which permit circularization in the fluid is also described. Factors which effect integration and circularization are disclosed. Therapeutic methods for retarding viral infection are also described.