The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 26, 1998

Filed:

Jan. 26, 1994
Applicant:
Inventors:

Stephen E Epstein, Rockville, MD (US);

Edith H Speir, Annandate, VA (US);

Ellis F Unger, Silver Spring, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07H / ; C12N / ; C12Q / ;
U.S. Cl.
CPC ...
514 44 ; 435375 ; 435377 ; 435-6 ; 536 245 ;
Abstract

The present invention provides a method of inhibiting restenosis of a blood vessel in a mammal after mechanical treatment of the vessel to reduce a stenosis. The method includes contacting proliferating smooth muscle cells in the vessel with an antisense oligonucleotide directed against a cellular division cycle gene product. This gene product can be one of the following: c-myc, PCNA, and cyclin B.sub.1. The antisense oligonucleotide is used in an amount effective to inhibit translation of the cellular division cycle gene product in the cell.

Published as:

Find Patent Forward Citations

Epstein, Stephen. (1998). Inhibition of cell proliferation using antisense oligonucleotides (U.S. Patent No. 5756476). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5756476

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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