The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 1998
Filed:
Jan. 26, 1994
Applicant:
Inventors:
Stephen E Epstein, Rockville, MD (US);
Edith H Speir, Annandate, VA (US);
Ellis F Unger, Silver Spring, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07H / ; C12N / ; C12Q / ;
U.S. Cl.
CPC ...
514 44 ; 435375 ; 435377 ; 435-6 ; 536 245 ;
Abstract
The present invention provides a method of inhibiting restenosis of a blood vessel in a mammal after mechanical treatment of the vessel to reduce a stenosis. The method includes contacting proliferating smooth muscle cells in the vessel with an antisense oligonucleotide directed against a cellular division cycle gene product. This gene product can be one of the following: c-myc, PCNA, and cyclin B.sub.1. The antisense oligonucleotide is used in an amount effective to inhibit translation of the cellular division cycle gene product in the cell.
Published as: