The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 1998
Filed:
Jun. 01, 1995
Enzo Paoletti, Delmar, NY (US);
Marion E Perkus, Altamont, NY (US);
Jill Taylor, Albany, NY (US);
James Tartaglia, Schenectady, NY (US);
Elizabeth K Norton, Latham, NY (US);
Michel Riviere, Ecully, FR;
Charles de Taisne, Lyons, FR;
Keith J Limbach, Troy, NY (US);
Gerard P Johnson, Waterford, NY (US);
Steven E Pincus, East Greenbush, NY (US);
William I Cox, Troy, NY (US);
Jean-Christophe Francis Audonnet, Albany, NY (US);
Russell Robert Gettig, Averill Park, NY (US);
Virogenetics Corporation, Troy, NY (US);
Abstract
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.