The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 1998
Filed:
Jun. 07, 1995
Joseph W Wyse, The Woodlands, TX (US);
Charles D Warner, The Woodlands, TX (US);
Aronex Pharmaceuticals, Inc., The Woodlands, TX (US);
Abstract
This invention discloses a novel cationic lipid acid salt of 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol. This invention further discloses a transmembrane compatible body suitable for transfection of animals and animal cells with nucleotides such as DNA, RNA, and synthetic nucleotides. Such transmembrane compatible bodies arise from hydratable non-liposomal halogenated solvent-free lyophilate comprising 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol and DOPE. This invention yet further discloses a halogenated solvent-free aqueous solution, suitable for lyophilization into a preliposomal powder, wherein the solution comprises 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol wherein substantially all 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol is dissolved.