The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 1998
Filed:
Jun. 05, 1995
Applicant:
Inventors:
Harry Meade, Newton, MA (US);
Nils Lonberg, New York, NY (US);
Assignee:
Pharming B.V., Leiden, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12P / ; C12P / ;
U.S. Cl.
CPC ...
426580 ; 435 691 ; 435 694 ; 435 6951 ; 435 6952 ; 435 696 ; 435183 ; 435215 ; 800-2 ; 800D / ;
Abstract
This invention relates to the production of recombinant proteins, such as coagulation factors VIII and IX, tissue plasminogen activator (TPA), urokinase, growth hormone, insulin, interferons, interleukins, peptide hormones and immunoglobulins, in mammals' milk. Particularly, this invention relates to an expression system which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This invention also relates to the transgenic mammal that produces the desired recombinant product in its milk.