The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 1998
Filed:
Apr. 14, 1995
Beverly L Davidson, Howell, MI (US);
Blake J Roessler, Ann Arbor, MI (US);
University of Michigan, Ann Arbor, MI (US);
Abstract
This invention provides recombinant adenoviral vectors having an expression control sequence operatively linked to a gene that encodes an anti-inflammatory polypeptide or that produces on transcription an anti-inflammatory ribozyme or antisense RNA molecule. This invention also provides methods of transferring a gene to a synovial cell by transducing the synovial cell in vivo, with a recombinant adenoviral vector. This invention also provides methods of treating an inflammatory condition in the joint of a subject comprising administering to the joint a therapeutically effective amount of a recombinant adenoviral vector having an expression control sequence operatively linked to a gene that encodes an anti-inflammatory polypeptide or that produces on transcription an anti-inflammatory ribozyme or antisense RNA molecule.