The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 1998
Filed:
Apr. 18, 1996
Alexander A Kolobov, Sestroretsk, RU;
Andrey S Simbirtsev, St.-Petersburg, RU;
Sergey V Kulikov, St.-Petersburg, RU;
Alexey N Prusakov, St. Petersburg, RU;
Natalia M Kalinina, St. Petersburg, RU;
Natalia V Pigareva, St. Petersburg, RU;
Alexander U Kotov, St. Petersburg, RU;
Vladimir M Shpen, St. Petersburg, RU;
Oleg A Kaurov, St. Petersburg, RU;
Sergey A Ketlinsky, St. Petersburg, RU;
Other;
Abstract
The new class of synthetic immunomodulatory molecules having a .gamma.-L-glutamyl- moiety at the amino terminus are provided as illustrated by Formula 1. ##STR1## In Formula 1, the Greek symbols designate the noted carbon atoms, R is hydrogen, acyl or alkyl, and X is an aromatic or heterocyclic amino acid or its derivative. Included as members of the new class (in addition to Bestim, .gamma.-L-glutamyl-L-tryptophan) are those compounds where R=hydrogen and X=L-tryptophan, such as .gamma.-L-glutamyl-N.sub.in -formyl-L-tryptophan, N-methyl-.gamma.-L-glutamyl-L-tryptophan, N-acetyl-.gamma.-L-glutamyl-L-tryptophan, and .gamma.-L-glutamyl-.beta.-thienyl-D-alanylamide. A preferred embodiment, termed 'BESTIM,' has the chemical structure of .gamma.-L-glutamyl-L-tryptophan.