The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 1998
Filed:
Nov. 21, 1994
Christopher Phillips, Brandamore, PA (US);
Sterling Winthrop, New York, NY (US);
Abstract
The present invention is directed to a method of labeling a protein conjugate with a radionuclide to form a radioconjugate comprising reacting: (a) the radionuclide; and (b) the protein conjugate in an acetate buffer for a time period and under conditions sufficient to form said radioconjugate. Preferably, the protein conjugate is comprised of a complexing agent moiety and a free epsilon amino group-containing protein moiety. The completing agent moiety is preferably a terpyridine analog. The terpyridine analog is preferably TMT. Preferably, the free epsilon amino group-containing protein moiety is an immunoreactive protein. The immunoreactive protein is preferably the monoclonal antibody ING-1. In a preferred embodiment, the protein conjugate is TMT-ING-1, and the radionuclide is .sup.90 Y. In a further preferred embodiment, the radioconjugate is chelated to greater than 98 percent of the radionuclide. Preferably, the acetate buffer in which the protein conjugate is present comprises at least about 50 mM sodium acetate.