The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 1998

Filed:

Jun. 05, 1995
Applicant:
Inventors:

Herman A Deboer, Roelofarendsveen, NL;

Rein Strijker, Oegstgeest, NL;

Herbert L Heyneker, Hillsborough, CA (US);

Gerard Platenburg, Voorschoten, NL;

Sang He Lee, Leiden, NL;

Frank Pieper, Utrecht, NL;

Paul J Krimpenfort, Heemstede, NL;

Assignee:

Pharming B.V., Leiden, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12P / ;
U.S. Cl.
CPC ...
800-2 ; 800D / ; 435 691 ; 935 60 ; 935 63 ;
Abstract

A transgenic bovine is disclosed whose somatic and germ cells contain a transgene, wherein the transgene comprising a mammary gland specific promoter, a mammary gland specific enhancer, a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells and a DNA sequence encoding a heterologous polypeptide of interest wherein the transgenic bovine expresses the transgene such that the polypeptide of interest is detectable in milk produced by the transgenic bovine.


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