The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 1998
Filed:
Apr. 02, 1997
Robert M Burk, Laguna Beach, CA (US);
Achim H Krauss, Foothill Ranch, CA (US);
David F Woodward, El Toro, CA (US);
Allergan, Waco, TX (US);
Abstract
A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering a therapeutically effective amount of a thromboxane ligand which is a compound of formula I, ##STR1## wherein Y is (CH.sub.2).sub.x ; Z is selected from the group consisting of ##STR2## x is an integer of 1 or 2; R.sub.2 is hydrogen or an alkyl radical of from 1 to 4 carbons, A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted or said alkylene or alkenylene may have one or more enchained oxo or imino radicals; B is a methyl radical, a cycloalkyl radical, or an aryl radical, or substituted derivatives of said methyl, cycloalkyl or aryl radicals and X is selected from the group consisting of nitro, cyano, --COOR, --CH.sub.2 OR.sub.1, --C(O)N(R.sub.1).sub.2, --CH.sub.2 N(R.sub.1).sub.2 --CH.dbd.N--OH and --CH.sub.2 SR.sub.1 radicals wherein R is a C.sub.1 to C.sub.10 alkyl, phenyl or benzyl and R.sub.1 is R or hydrogen; or a pharmaceutically acceptable salt thereof.