The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 1998
Filed:
Jun. 07, 1995
Sven Hastrup, K.o slashed.benhavn NV, DK;
Sven Branner, Lyngby, DK;
Fanny Norris, Hellerup, DK;
Steffen Bjo Petersen, Ballerup, DK;
Leif No slashed.rskov-Lauridsen, K.o slashed.ge, DK;
Villy Johannes Jensen, Bagsvaerd, DK;
Dorrit Aaslyng, Roskilde, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess altered chemical properties including, but not limited to, increased stability to oxidation, augmented proteolytic activity, and improved washability. The present invention also relates, but is not limited to, the amino acid and DNA sequences for two proteases derived from Bacillus lentus variants, subtilisin 147 and subtilisin 309, as well as mutations of these genes and the corresponding mutant enzymes.