The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 1998
Filed:
Mar. 16, 1995
Applicant:
Inventors:
D Scott Wilbur, Edmonds, WA (US);
Pradip M Pathare, Seattle, WA (US);
A Charles Morgan, Jr, Camino Island, WA (US);
Assignees:
University of Washington, Seattle, WA (US);
Receptagen Corp., Edmonds, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07H / ; C07K / ;
U.S. Cl.
CPC ...
530367 ; 514-2 ; 514-8 ; 514 52 ; 530409 ; 536 264 ; 536 2641 ; 5483037 ;
Abstract
A biotinylated cobalamin, formed from a vitamin B.sub.12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B.sub.12 molecule is cyanocobalamin. The biotin molecule can also be coupled to a rerouting moiety, optionally through a biotin binding protein such as avidin or streptavidin. The biotinylated cobalamin binds to a cell surface receptor, is invaginated, and once internalized affects the receptor trafficking pathway.