The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 1998
Filed:
Jul. 15, 1994
Takeda Chemical Industries, Ltd., Osaka, JP;
Abstract
A solid pharmaceutical preparation containing 5 to 50% by weight of ibuprofen and 0.1 to 10% by weight of phenylpropionamide or a pharmaceutically acceptable salt thereof which are stabilized. The solid pharmaceutical preparation can be produced by means of granulating with carriers at least one active ingredient, preferably both ingredients separately into the ibuprofen group and the phenylpropanolamine group, and mixing the former with the latter to enhance the stability of the active ingredients. Preferably, in the phenylpropanolamine group, the amount of any reducing sugar is minimized to such an extent as to maintain the stability of the active ingredient. The above pharmaceutical preparation is suitable for a cold remedy, which has a more excellent pharmacological activity based on ibuprofen, less decomposability of phenylpropanolamine and less change of external appearance of the preparation due to low compatibility between phenylpropanolamine and ibuprofen. Therefore, the pharmaceutical preparation has a longer period of quality assurance.