The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 1998

Filed:

Jun. 01, 1995
Applicant:
Inventors:

Gerhard Becker, Buhl Baden, DE;

Paul Marcel Larson, Malsch, DE;

Reiner Heidl, Asslar-Werdorf, DE;

Assignee:

Sanorell Pharma GmbH & Co., Baiersbronn, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; G01N / ; C02E / ;
U.S. Cl.
CPC ...
435 31 ; 435 29 ; 435 34 ; 435 39 ; 435261 ; 436146 ; 436148 ; 436175 ; 436825 ; 210637 ; 210650 ; 210651 ; 422 8213 ; 422 88 ;
Abstract

This invention provides a process for checking the removal rate of pyrogenic substances, in particular viruses, from organic material. The material to be purified is passed through an ultrafilter or an ultrafiltration unit whose virus-removal rate has already been determined by passing viruses of the Leviviridae family or other comparable small bacteriophages through the filter or filtration unit, the virus titer is determined before and after the filtration operation and the virus removal rate thus calculated. Before or after determining the virus-removal rate, a given pressure is applied to the filter or filtration unit in a gas pressure-hold test, and the decrease in the pressure over a given period is measured. After filtration of the biological material, the rate of virus removal by the filter is checked by repeating the pressure-hold test.


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