The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 1998

Filed:

Dec. 19, 1995
Applicant:
Inventors:

Tsuyoshi Aoki, Fukushima, JP;

Atsuo Takahashi, Fukushima, JP;

Hiroyasu Sato, Fukushima, JP;

Eiji Shimanuki, Fukushima, JP;

Kaoru Gengyou, Fukushima, JP;

Toyoki Nishimata, Fukushima, JP;

Sachiko Ishigami, Fukushima, JP;

Shin-ichi Yamada, Fukushima, JP;

Takahiro Yamaguchi, Fukushima, JP;

Yoichi Manome, Fukushima, JP;

Isamu Sato, Fukushima, JP;

Kentaro Kogi, Miyagi, JP;

Sen-ichi Narita, Saitama, JP;

Assignee:

Toa Eiyo, Ltd., Tokyo, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
546194 ; 514318 ; 514330 ; 546225 ;
Abstract

A substituted cyclic amine compound represented by the following general formula (1) ##STR1## wherein each of R.sup.1 to R.sup.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or .dbd.N(.fwdarw.O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.


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