The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 1998
Filed:
Jun. 05, 1995
Kuo-Hsiung Lee, Chapel Hill, NC (US);
Yoshiki Kashiwada, Chapel Hill, NC (US);
Li Huang, Chapel Hill, NC (US);
Thomas Tung-Ying Lee, Chapel Hill, NC (US);
Mark Cosentino, Springfield, VA (US);
Jim Snider, Hagerstown, MD (US);
Mark Manak, Laurel, MD (US);
Lan Xie, Chapel Hill, NC (US);
Biotech Research Laboratories, Rockville, MD (US);
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Abstract
The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. The invention is also directed to methods of making these compounds, pharmaceutical compositions including these compounds and methods of using the compounds to inhibit retroviral infections in cells and tissues of animals. A method for stereoselectively preparing compounds within the scope of the invention by catalytic asymmetric dihydroxylation is also disclosed.