The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 1998
Filed:
Feb. 13, 1996
Takuji Hirose, Tsukuba, JP;
Kazuyuki Kasuga, Tsuchiura, JP;
Hideki Sugihara, Tsukuba, JP;
Yuichiro Himeda, Tsukuba, JP;
Zhen-He Wang, Tsukuba, JP;
Bruce Baldwin, Tsukuba, JP;
Abstract
Disclosed is a novel compound having activity as an ionophore for ion transport, which is a monoester or monoamide of 1,3,5-trimethyl-1,3,5-cyclohexane tricarboxylic acid, i.e. Kemp's triacid or the stereoisomer thereof, the group R in the ester group --COOR or in the amide group --CONHR being an aralkyl group or aryloxyalkyl group having 7 to 20 carbon atoms. The monoester and monoamide derivatives can be synthesized from anhydride of Kemp's triacid by subjecting the anhydride to a ring-opening esterification or amidation reaction with an alcohol or amine. On the other hand, both of the stereoisomers can be obtained by the dehydrohalogenation reaction of 1,3,5-trimethyl-1,3,5-cyclohexane tricarboxylic acid anhydride acid halide with an alcohol or amine followed by the ring-opening hydrolysis reaction on the anhydride group.