The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 1998

Filed:

Jan. 16, 1996
Applicant:
Inventors:

Frank Gentile, Warwich, RI (US);

Molly Shoichet, Toronto, CA;

Milton Harris, Huntersville, AL (US);

Assignee:

CytoTherapeutics, Inc., Providence, RI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08L / ; C08L / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
424424 ; 525187 ; 5253291 ; 5253292 ; 525385 ; 21050023 ; 21050043 ; 435182 ;
Abstract

A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer and grafting polyalkylene oxide polymer chains to the backbone polymer through the reactive sites. Either the backbone polymer of a polymer resin or a permselective polymer membrane can be grafted. When a resin is used, it is formed into a permselective polymer membrane using known methods. The resulting permselective membrane can be formed into hollow fibers or flat sheets for the encapsulation of living cells. The encapsulated cells are then implanted into a patient in need of the biologically-active factors produced by the cells. The permselective graft polymer membrane exhibits good molecular diffusion with minimal protein adsorption.


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