The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 1998
Filed:
Jun. 06, 1995
Nizal Samuel Chandrakumar, Vernon Hills, IL (US);
Barbara Baosheng Chen, Glenview, IL (US);
Michael Clare, Skokie, IL (US);
Bipinchandra Nanubhai Desai, Vernon Hills, IL (US);
Stevan Wakefield Djuric, Malvern, PA (US);
Stephen Hermann Docter, Mt. Prospect, IL (US);
Alan Frank Gasiecki, Vernon Hills, IL (US);
Richard Arthur Haack, Chicago, IL (US);
Chi-Dean Liang, Glenview, IL (US);
Julie Marion Miyashiro, Chicago, IL (US);
Thomas Dale Penning, Elmhurst, IL (US);
Mark Andrew Russell, Gurnee, IL (US);
Stella Siu-tzyy Yu, Morton Grove, IL (US);
G.D. Searle & Co., Chicago, IL (US);
Abstract
The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.