The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 17, 1998

Filed:

Jun. 07, 1995
Applicant:
Inventors:

Claude Thal, Sceaux, FR;

Catherine Quirosa-Guillou, Verrieres Le Buisson, FR;

Pierre Potier, Paris, FR;

Dolor Renko, Gif Sur Yvette, FR;

Jean-Pierre Zanetta, Griesheim/Souffel, FR;

Marie-Madeleine Portier, Verrieres Le Buisson, FR;

Monique Sensenbrenner, Strasbourg, FR;

Janine Koenig, Bordeaux, FR;

Herbert Koenig, Bordeaux, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ;
U.S. Cl.
CPC ...
514634 ; 514716 ; 560159 ; 564237 ; 564240 ;
Abstract

Guanidine derivatives are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies. The compounds have the formula: ##STR1## wherein R.sub.1 is an isopropyl radical, a benzyl radical which is optionally substituted by one or more (C.sub.1 -C.sub.6)alkoxy radicals or a radical: ##STR2## R.sub.2, R.sub.3 and R.sub.4 together with the nitrogen atoms to which they are attached and the carbon atom to which the said nitrogen atoms are attached form a pyrimidine ring of formula II or a pyrimidinium ring of formula IIa: ##STR3##


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