The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 1998
Filed:
Jul. 16, 1996
Applicant:
Inventors:
Yoshinori Yamamoto, Sendai, JP;
Hisao Nemoto, Tokushima, JP;
Assignee:
President of Tohoku University, Sendai, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F / ; C07F / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
534 16 ; 568-4 ; 564-8 ; 424-165 ; 424-9364 ;
Abstract
The present invention provides a gadolinium-DTPA complex containing a carborane unit having structural formula (1) given below and an intermediate thereof, i.e., carborane-containing DTPA derivative represented by formula (2) given below. ##STR1## The present invention also provides a method of synthesizing the compound (1), which comprises reacting an ester derivative of DTPA with a carborane derivative in the presence of a palladium catalyst, deesterifying by treatment with an acid, reacting with gadolinium trichloride hexahydrate, and treating with an alkali to give the desired compound (1).