The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 1998
Filed:
Jun. 06, 1995
Applicant:
Inventors:
John A Mankovich, Andover, MA (US);
Linda Hammill, Townsend,, MA (US);
Catherine R Ferenz, Belchertown, MA (US);
Assignee:
BASF Aktiengesellschaft, Federal Republic of Germany, DE;
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C07H / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 691 ; 4352542 ; 4352557 ; 4353201 ; 435325 ; 536 231 ; 536 241 ;
Abstract
Hybrid genes comprising a nucleotide sequence encoding a preprocollagen signal sequence operatively linked to a nucleotide sequence encoding a heterologous protein are disclosed. The hybrid genes are useful for secretion of heterologous proteins from host cells. In a preferred embodiment, the signal sequence of the human preprocollagen .alpha.1(I) protein is linked to a heterologous protein of interest to allow for secretion of the protein from Hansenula polymorpha cells.