The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 1998
Filed:
May. 26, 1994
Applicant:
Inventors:
Rudolf Hauptmann, Ebreichsdorf, AT;
Edgar Falkner, Vienna, AT;
Gerhard Bodo, Vienna, AT;
Tilman Voss, Modling, AT;
Ingrid Maurer-Fogy, Vienna, AT;
Assignee:
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 6951 ; 435 6958 ; 4353201 ; 43525233 ; 530412 ; 530415 ; 530416 ; 536 234 ; 536 2352 ; 536 241 ;
Abstract
Methods and vectors for expressing interferon-alpha (IFN-.alpha.) proteins in E. coli are provided. Use of a vector comprising an IFN-.alpha. sequence fused to an E. coli heat-stable enterotoxin signal sequence (STII) under the control of the E. coli phosphatase (phoA) promoter affords high levels of correctly-folded and -processed, biologically active IFN-.alpha. polypeptides.