The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 1998
Filed:
May. 06, 1996
John E Smart, Weston, MA (US);
Hermann Oppermann, Medway, MA (US);
Engin Ozkaynak, Milford, MA (US);
Thangavel Kuberasampath, Medway, MA (US);
David C Rueger, Hopkinton, MA (US);
Roy H Pang, Etna, NH (US);
Charles M Cohen, Medway, MA (US);
Creative BioMolecules, Inc., Hopkinton, MA (US);
Abstract
In one aspect, the present invention provides a method of diagnosing renal tissue damage or disease by measuring endogenous expression of OP-1 by renal tissue of a mammal (e.g., a human) in which a depression of endogenous expression relative to undamaged or undiseased mammalian renal tissue indicates a diagnosis that the mammal is afflicted with renal tissue damage or disease. Also disclosed are methods of diagnosing renal tissue damage or disease in a mammal. The methods involve detecting and/or measuring the expression of the OP-1 (BMP-7) gene or protein in the mammal. Depression of OP-1 expression may be used to diagnose renal tissue damage or disease.