The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 1998
Filed:
May. 22, 1995
Applicant:
Inventor:
Arlen R Thomason, Thousand Oaks, CA (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ; A61K / ;
U.S. Cl.
CPC ...
514 12 ; 530350 ; 530399 ; 536 234 ; 435 697 ; 435325 ;
Abstract
The present invention provides a biologically active multimeric polypeptide molecule in which two or more monomeric subunits are linked together as a single polypeptide ('fusion multimer'). These fusion multimers are more easily and rapidly refolded than unfused multimers, because the reactions necessary to generate the biologically active multimeric form of the polypeptide proceed with first order, rather than second or higher order, reaction kinetics. Fusion multimers also eliminate the simultaneous formation of undesired polypeptide by-products during refolding. The fusion multimers of the present invention specifically include PDGF fusion dimers.