The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 1998

Filed:

Jun. 07, 1995
Applicant:
Inventors:

Thomas Brendan Ryder, Escondido, CA (US);

Karen W Shannon, Escondido, CA (US);

Daniel Louis Kacian, San Diego, CA (US);

Richard C Harvey, San Diego, CA (US);

Sherrol H McDonough, San Diego, CA (US);

Frank R Gonzales, San Diego, CA (US);

Maria R Castillo, Chula Vista, CA (US);

Elizabeth R Billyard, San Diego, CA (US);

Nancy Lau Shen, San Diego, CA (US);

Assignee:

Gen-Probe Incorporated, San Diego, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; C12P / ; C07H / ; C07H / ;
U.S. Cl.
CPC ...
435 911 ; 435-6 ; 435 912 ; 536 221 ; 536 231 ; 536 243 ; 536 2433 ; 536 2532 ;
Abstract

Methods and kits for relating initial amounts of target nucleic acids present in a sample to target-specific amplification products. It has been discovered that the transcription-mediated amplification system is capable of producing a quantitative relationship between target input and target-specific output. Further, the the present invention relates to methods for carefully controlling this relationship resulting in an unexpectedly high degree of reproducability. Also described are useful methods for extending the dynamic range of transcription-based amplification systems.


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