The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 1998
Filed:
Mar. 07, 1995
Applicant:
Inventors:
Eddie Reed, Germantown, MD (US);
Meenakshi Dabholkar, Bethesda, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q / ; C07H / ; C12P / ;
U.S. Cl.
CPC ...
435-6 ; 435 912 ; 435 9121 ; 435 915 ; 435 9151 ; 436 63 ; 436 64 ; 536 2431 ; 536 2433 ; 935 77 ; 935 78 ;
Abstract
Assay of the mRNA levels of ERCC1 and XPAC, two genes whose products are involved in DNA repair, provides a method for determining the sensitivity of tumors to treatment by platinum-based chemotherapy. Tumors that are resistant to cisplatin tend to express high levels of the mRNA for ERCC1 which includes exon VIII. In some tumor types, concurrent expression of ERCC1 and XPAC mRNAs is also an indicator of cisplatin resistance.