The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 1997
Filed:
Apr. 13, 1995
Applicant:
Inventors:
Michael S Urdea, Alamo, CA (US);
Thomas Horn, Berkeley, CA (US);
Assignee:
Chiron Corporation, Emeryville, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H / ;
U.S. Cl.
CPC ...
536 231 ; 536 221 ; 536 243 ; 536 2431 ; 536 2432 ; 536 253 ; 536 2534 ; 536 255 ; 536 268 ; 536 2761 ; 536 2763 ; 536 285 ; 536 2851 ; 536 2852 ; 435-6 ;
Abstract
Hydroxyl-protecting groups orthogonally removable by reduction with a liquid reducing agent are disclosed. The novel hydroxyl-protecting groups are particularly useful in the chemical synthesis of linear and branched oligonucleotide structures, as they are readily removed from the protected molecule with mild reagents such as dithionite. Examples of such hydroxyl-protecting groups include the 2-methylene-9,10-anthraquinone (Maq) carbonate ester and the p-nitrobenzyl carbonate ester.