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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5703092 B1

PDFFull Text
Date of Patent:
Dec. 30, 1997

Filed:

Apr. 16, 1996

Hydroxamic acid compounds as metalloprotease and tnf inhibitors

Applicant:
Inventors:

Chu-Biao Xue, Hockessin, DE (US);

William F DeGrado, Philadelphia, PA (US);

Carl Peter DeCicco, Newark, DE (US);

Irina Cipora Jacobson, Boothwyn, PA (US);

Assignee:

The DuPont Merck Pharmaceutical Company, Wilmington, DE (US);

Attorney:

Kondrad; Karen H.

Primary Examiner:

Bernard Dentz

Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514303 ; 514394 ; 514399 ; 546334 ; 546118 ; 5483097 ; 548180 ; 548204 ; 548217 ; 548235 ; 548247 ; 548253 ; 5483381 ; 5483751 ; 562623 ;
Abstract

The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as stromelysin and other matrix metalloproteinases, and also inhibit the production of tumor necrosis factor (TNF), and are therefore useful for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula I below: ##STR1##

Find Patent Forward Citations

Xue, Chu-Biao. (1997). Hydroxamic acid compounds as metalloprotease and tnf inhibitors (U.S. Patent No. 5703092). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5703092

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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