The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 1997
Filed:
Nov. 20, 1995
Joong-Hyup Kim, Seoul, KR;
Sung Hoon Kim, Seoul, KR;
Ghil Soo Nam, Seoul, KR;
Ha Young Kim, Seoul, KR;
Hyen Joo Son, Seoul, KR;
Korea Institute of Science and Technology, Seoul, KR;
Abstract
1-N-ethylsisomicin represented by the following structural formula I and pharmaceutically acceptable salts thereof are useful antibacterial agents and can be prepared in high yields by a characteristic method comprising the steps of: chelating sisomicin with a chelating agent in a protic solvent; protecting the 3-,2'-and 6'-amino groups of the chelated sisomicin derivative with an acylating reagent; removing the chelating metal from the sisomicin derivative by use of ammonia water, to obtain a 3, 2', 6-N-trisubstituted sisomicin derivative; reacting the trisubstituted sisomicin derivative with an ethylating reagent in an aprotic organic solvent, to selectively ethylate the 1-amino group of the trisubstituted sisomicin derivative; and deprotecting the ethylated sisomicin derivative: ##STR1##