The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 1997
Filed:
Oct. 22, 1992
David J Baylink, Redlands, CA (US);
Subburaman Mohan, Redlands, CA (US);
Boehringer Mannheim GmbH, Mannheim, DE;
Abstract
The invention provides homogeneous compositions of a binding protein for insulin-like growth factors (IGFs) I and II, which binding protein inhibits the proliferative effects of IGF-I and IGF-II upon bone cells. The homogeneous protein of the invention is therefore known as inhibitory IGF binding protein, or In-IGF-BP. The invention also provides cloned nucleic acid sequences encoding In-IGF-BP, artificial expression systems for In-IGF-BP and host cells which produce useful quantities of In-IGF-BP. The invention further provides clinical diagnostic assays for IGFs, therapeutic treatments for IGF-responsive tumors, and means for modulating IGF activity upon bone cells.