The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 25, 1997

Filed:

May. 25, 1995
Applicant:
Inventors:

Hans Albertsen, Salt Lake City, UT (US);

Rakesh Anand, Sandbach, GB;

Mary Carlson, Salt Lake City, UT (US);

Joanna Groden, Salt Lake City, UT (US);

Philip John Hedge, Winsford, GB;

Geoff Joslyn, Salt Lake City, UT (US);

Kenneth Kinzler, Baltimore, MD (US);

Alexander Fred Markham, Crewe, GB;

Yusuke Nakamura, Tokyo, JP;

Andrew Thliveris, Salt Lake City, UT (US);

Bert Vogelstein, Baltimore, MD (US);

Raymond L White, Salt Lake City, UT (US);

Assignees:

The Johns Hopkins University, Baltimore, MD (US);

University of Utah, Salt Lake City, UT (US);

the Cancer Institute, London, GB;

Imperial Chemical Industries PLC, Tokyo, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
5303877 ; 5303879 ; 5303888 ; 5303897 ; 536 235 ;
Abstract

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.


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