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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5691307 B1

PDFFull Text
Date of Patent:
Nov. 25, 1997

Filed:

Jun. 07, 1994

O.sup.6 -substituted guanine compositions and methods for depleting o.sup.6

Applicant:
Inventors:

Robert C Moschel, Frederick, MD (US);

M Eileen Dolan, Oak Park, IL (US);

Anthony E Pegg, Hershey, PA (US);

Mark G McDougall, Cleveland, OH (US);

Mi-Young Chae, Frederick, MD (US);

Assignees:

The United States of America as represented by the Department of Health, , US;

The Penn State Research Foundation, University Park, PA (US);

Arch Development Corporation, Chicago, IL (US);

Attorney:

Leydig, Voit & Mayer, Ltd.

Primary Examiner:

Matthew V Grumbling

Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514 12 ; 514 13 ; 514 14 ; 514 15 ; 514 16 ; 514 18 ; 514 19 ; 514 20 ; 514262 ; 514 26 ; 514 27 ; 514 44 ; 514 45 ; 514 48 ; 514950 ; 514 81 ; 514245 ; 514183 ; 514589 ; 514256 ; 514771 ; 514417 ; 514414 ; 544276 ; 536-5 ; 536 173 ; 536 241 ; 530324 ; 530325 ; 530326 ; 530327 ; 530328 ; 530329 ; 530330 ; 530278 ;
Abstract

Novel O.sup.6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O.sup.6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful for treating tumors and when used with anti-neoplastic alkylating agents enhance the chemotherapeutic treatment of tumor cells in a host.

Find Patent Forward Citations

Moschel, Robert. (1997). O.sup.6 -substituted guanine compositions and methods for depleting o.sup.6 (U.S. Patent No. 5691307). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5691307

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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