The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 1997
Filed:
Jun. 06, 1995
Applicant:
Inventors:
James E Dahlberg, Madison, WI (US);
Victor I Lyamichev, Madison, WI (US);
Mary Ann Brow, Madison, WI (US);
Assignee:
Third WaveTechnologies, Inc., Madison, WI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; C12P / ; C07H / ; G01N / ;
U.S. Cl.
CPC ...
435-6 ; 435 912 ; 435183 ; 436 94 ; 536 243 ; 536 2433 ; 935 78 ;
Abstract
A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. In this novel detection method, the signal indicative of the presence of the target nucleic acid sequence is amplified through cleavage of detection molecule(s) which comprise hairpin structures.