The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 1997
Filed:
Nov. 13, 1995
Edward A Deutsch, Maryland Heights, MO (US);
Karen F Deutsch, Maryland Heights, MO (US);
William P Cacheris, Florissant, MO (US);
William H Ralston, St. Charles, MO (US);
David H White, Ballwin, MO (US);
Dennis L Nosco, Florissant, MO (US);
Robert G Wolfangel, Ballwin, MO (US);
Janet Braddock Wilking, Ferguson, MO (US);
Linda Meeh, St. Louis, MO (US);
Steven R Woulfe, Ballwin, MO (US);
Mallinckrodt Medical, Inc., St. Louis, MO (US);
Abstract
Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ('MRI'), magnetic resonance spectroscopy ('MRS'), magnetic resonance spectroscopy imaging ('MRSI'), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described apatite particles and then performing the medical diagnostic procedure.