The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 1997
Filed:
Oct. 28, 1994
Applicant:
Inventors:
E Antonio Chiocca, Boston, MA (US);
David J Waxman, Newton Centre, MA (US);
Ming X Wei, Somerville, MA (US);
Xandra O Breakefield, Newton, MA (US);
Ling Chen, Brookline, MA (US);
Assignees:
The General Hospital Corporation, Boston, MA (US);
Boston University, Boston, MA (US);
Dana-Farber Cancer Institute, Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; C07N / ;
U.S. Cl.
CPC ...
514 44 ; 424 931 ; 424 9321 ; 4351723 ; 4352401 ; 4352402 ; 43524025 ; 4353201 ;
Abstract
A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene product targets the cells for selective killing, by rendering the cells sensitive to a chemotherapeutic agent.