The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 1997

Filed:

Sep. 12, 1994
Applicant:
Inventors:

Kwong Y Tsang, Bethesda, MD (US);

Myron Arlen, Great Neck, NY (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N / ; G01N / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
435-723 ; 435-71 ; 435-72 ; 435 4051 ; 435 4052 ; 435325 ; 435328 ; 435329 ; 435330 ; 435332 ; 435344 ; 5303888 ; 5303871 ; 5303873 ; 5303875 ; 5303877 ; 5303881 ; 5303911 ; 5303913 ; 5303917 ;
Abstract

Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/human chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fragments and derivatives thereof, are useful in immunodiagnosis and immunotherapy of human colon, breast, and ovarian cancer, and for purification of antigens which can serve as immunotherapeutic agents. Methods of detecting the colon carcinoma-associated antigen in a sample, and methods for treating subjects having colon, breast, and ovarian carcinomas are disclosed.


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