The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 1997
Filed:
Sep. 19, 1996
Applicant:
Inventors:
Mitree M Ponpipom, Branchburg, NJ (US);
William K Hagmann, Westfield, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
544242 ; 544264 ; 544336 ; 544358 ; 546152 ; 546193 ; 546249 ; 548152 ; 548206 ; 548213 ; 548215 ; 548221 ; 5483351 ; 5483435 ; 548250 ; 548440 ; 548469 ; 548470 ; 548489 ; 548491 ; 548530 ; 549-6 ; 549 23 ; 549 30 ; 549 33 ; 549 49 ; 549229 ; 549266 ; 549273 ; 549307 ; 549313 ; 568735 ;
Abstract
Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. This invention relates to a process of making the carboxy-peptidyl compounds of formula I. ##STR1##