The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 1997
Filed:
May. 26, 1995
Celltech Therapeutics Limited, Berkshire, GB;
Abstract
##STR1## Conjugate compounds are described comprising a compound of formula (1), wherein A is a group --Alk.sup.3 -- or --Alk.sup.3 N(R.sup.4)Alk.sup.1 --, Alk.sup.2, Alk.sup.3 and Alk.sup.4 which may be the same or different is each a C.sub.1-4 alkylene chain optionally substituted by one or more C.sub.1-6 alkyl groups; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, is each a hydrogen atom or a group--AlkR.sup.5 where Alk is an optionally substituted straight or branched C.sub.1-6 alkyl group and R.sup.5 is a hydrogen atom or a --CO.sub.2 H, --CONR.sup.6 R.sup.7 (where R.sup.6 and R.sup.7, which may be the same or different is each a hydrogen atom or an alkyl group) or --P(X.sup.1)(X.sup.2 R.sup.8)L group where X.sup.1 and X.sup.2 is each an oxygen or sulphur atom. R.sup.8 is a hydrogen atom or an alkyl group and L is an aliphatic, aromatic, or heteroaromatic group or a linker group with the proviso that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group AlkP(X.sup.1)(X.sup.2 R.sup.8)L where L is a linker group; and a metal complexes and/or salts thereof, coupled to a protein, peptide or carbohydrate. The conjugates are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours.