The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 1997
Filed:
Oct. 09, 1996
Neil Roy Curtis, Puckeridge, GB;
Janusz Jozef Kulagowski, Bishops Stortford, GB;
Paul David Leeson, Monmouth Junction, NJ (US);
Merck, Sharp & Dohme, Ltd., Hoddesdon, GB;
Abstract
The methanesulfonate salt of a class of antipsychotic compounds comprising a benzo�b!furan moiety and a substituted heterocyclic moiety, linked via the 3-position of the benzo�b!furan moiety by a methylene group, which are antagonists of dopamine receptor subtypes within the brain, being extremely potent antagonists of the human dopamine D.sub.4 receptor subtype and having a selective affinity for the D.sub.4 subtype over other dopamine receptor subtypes, possess advantageous qualities in terms of their improved aqueous solubility relative to the corresponding free base and, as such, provide for greater ease of formulation and display enhanced pharmacokinetic properties, including oral absorption.