The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 1997
Filed:
Sep. 05, 1990
Miryana Burnouf-Radosevich, Wavrin, FR;
Thierry Burnouf, Wavrin, FR;
Centre Regional de Transfusion Sanguine de Lille, Lille, FR;
Abstract
The invention relates to a process for preparing a concentrate of Factor VIII-von Willebrand factor complex having high specific activity from total (non-cryoprecipitated) plasma. The process comprises pre-purifying by means of a double treatment with barium chloride and with aluminium hydroxide. The process then comprises purification by chromatography on an anion exchange resin, of the DEAE-Fractogel type. The process includes a step of viral inactivation by means of a treatment with solvent-detergent. The process also makes it possible to recover fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex, from the same plasma. The different concentrates obtained using the process according to the invention are intended, in particular, for therapeutic use.