The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 1997
Filed:
May. 31, 1994
Lawrence M Kauvar, San Francisco, CA (US);
Matthew H Lyttle, Point Reyes Station, CA (US);
Terrapin Technologies, Inc., San Francisco, CA (US);
Abstract
Compounds of the formula: ##STR1## or a salt thereof, wherein n is 1 or 2; wherein when n is 1, X is a mono- or disubstituted or unsubstituted C.sub.1-20 hydrocarbon radical wherein any substitution is selected from the group consisting of halo, OR, and SR, wherein R is H or C.sub.1-4 alkyl; and wherein, when n is 2, one X is defined as for n=1 and the other X is lower C.sub.1-4 alkyl; ##STR2## wherein m is 1 or 2; AA.sub.C is an amino acid coupled through a peptide bond to the remainder of the compound of Formula (1) selected from the group consisting of glycine, valine, alanine, 4-aminobutyric acid, aspartic acid, phenylglycine, histidine, tryptophan, tyrosine, and phenylalanine, wherein the phenyl group of phenylalanine or phenylglycine may optionally contain a single substitution selected from the group consisting of halo, OR, and SR, wherein R is H or C.sub.1-4 alkyl; with the proviso that if Y is ##STR3## AA.sub.C is not Gly; and if Y is ##STR4## and X is benzyl, AA.sub.C cannot be Val are useful as affinity ligands and as diagnostic reagents. These compounds and analogous tripeptide glutathione analogs can be used as members of panels to obtain specific characteristic profiles for various glutathione-S-transferases.