The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 1997
Filed:
Jun. 07, 1995
Przemyslaw Szafranski, Boston, MA (US);
Charlene M Mello, Rochester, MA (US);
Takeshi Sano, Boston, MA (US);
Kenneth A Marx, Francestown, NH (US);
Charles R Cantor, Boston, MA (US);
David L Kaplan, Stow, MA (US);
Cassandra L Smith, Boston, MA (US);
Trustees of Boston University, Boston, MA (US);
The United States of America as Represented by the Secretary of the Army, Washington, DC (US);
Abstract
The present invention relates to genetic containment systems which express a biotin-binding component that can be used for selectively destroying recombinant cells such as genetically engineered microorganisms. These systems may comprise a streptavidin or an avidin gene whose expression is controlled by a regulatable promoter. The regulatory agent such as a transcriptional effector is expressed from another gene which may also be expressed and its expression controlled by the containment system. Expression of the agent can be designed to respond to physiological changes in the environment. The invention also relates to containment systems and methods for the selective detection or tracking of recombinant cells and to eukaryotic and prokaryotic cells which contain these genetic containment systems.