The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 1997
Filed:
Jun. 01, 1995
Applicant:
Inventors:
Paul Torrence, Silver Spring, MD (US);
Robert Silverman, Shaker Heights, OH (US);
Ratan Maitra, Euclid, OH (US);
Krystyna Lesiak, Gaithersburg, MD (US);
Assignees:
The Cleveland Clinic Foundation, Cleveland, OH (US);
The United States of America, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07H / ; C12Q / ;
U.S. Cl.
CPC ...
514 74 ; 514 46 ; 514 47 ; 436 94 ; 435-6 ; 435 911 ; 435199 ; 4352402 ; 536 245 ; 536 252 ;
Abstract
A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.