The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 1997
Filed:
May. 18, 1995
Applicant:
Inventors:
Philip Leder, Chestnut Hill, MA (US);
Brian Seed, Boston, MA (US);
Ben Z Stanger, Brookline, MA (US);
Tae-Ho Lee, Daejeon, KR;
Emily Kim, Chestnut Hill, MA (US);
Assignees:
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C07H / ; C07H / ; C12P / ;
U.S. Cl.
CPC ...
4352523 ; 536 231 ; 536 235 ; 536 234 ; 435 691 ; 435 699 ; 435183 ; 530350 ;
Abstract
Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.