The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 1997
Filed:
Sep. 23, 1994
Applicant:
Inventors:
Bang-Chi Chen, Manilus, NY (US);
Derron Ray Stark, Syracuse, NY (US);
Stephen Richard Baker, Cicero, NY (US);
Sandra L Quinlan, Manlius, NY (US);
Assignee:
Bristol-Myers Squibb Co., New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C07H / ;
U.S. Cl.
CPC ...
536 553 ; 536 2854 ;
Abstract
An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'.alpha.-halo-3'.alpha.-alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product.