The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 1997
Filed:
Mar. 11, 1996
Applicant:
Inventors:
Lawrence J MacPherson, Hampton, NJ (US);
David Thomas Parker, Livingston, NJ (US);
Assignee:
Novartis Corporation, Summit, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
514357 ; 5142378 ; 514311 ; 514331 ; 514332 ; 514341 ; 514365 ; 514396 ; 514406 ; 514432 ; 514445 ; 514451 ; 514602 ; 514604 ; 540524 ; 540531 ; 544 581 ; 544168 ; 544130 ; 544131 ; 544133 ; 546175 ; 546194 ; 546209 ; 546247 ; 546265 ; 5462834 ; 5462821 ; 546333 ; 546337 ; 5462804 ; 5462844 ; 5462817 ; 5462751 ; 548205 ; 5483351 ; 5483381 ; 549 13 ; 549 65 ; 549426 ; 564 84 ; 564 90 ; 564 92 ; 564 94 ;
Abstract
Disclosed are the compounds of formula I ##STR1## wherein R and R.sub.1 together with the chain to which they are attached or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a ring; pharmaceutically acceptable prodrug derivatives and pharmaceutically salts thereof; methods of preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds.